The aim is to formulate non effervescent gastroretentive floating drug delivery of Celecoxib that would retain the drug in stomach and continuously release the drug in a controlled manner in a predetermined time proposed leading to improved bioavailability. The selection of polymer which is able to release the drug in controlled fashion with initial burst, release of drug to initial therapeutic level quickly. Solvent evaporation was used to prepare the microparticulates and evaluated for buoyancy, density, particle size, SEM, in vitro dissolution, in vitro permeation and in vivo studies. Densities of microparticulates were found less than the density of gastric fluid. In vitro release followed diffusion with Higuchi spherical matrix release and ‘n’ value suggested non-Fickian diffusion. Ethylcellulose microparticulates demonstrated initial rapid drug release followed by prolonged phase. In vitro permeation of all microparticulates followed zero order and the mechanism was confirmed by ‘n’ value, suggested super case II transport mechanism. Microparticulates showed excellent stabilityand the in vivo Anti-Inflammatory studies hold promising results for management of inflammation 12 hours. Present investigation holding the novel and promising results to prove a suitable sustained release floating drug delivery system.
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